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If bupropion is added to the treatment regimen of a patient already receiving a drug metabolized by cyp2d6, the need to decrease the dose of the original medication should be considered, particularly for those concomitant medications with a narrow therapeutic index.

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Observe patients for neuropsychiatric symptomssuch as changes in behaviorhostilityagitationdepressed moodand suicide-related eventsincluding ideationbehaviorand attempted suicidesee Black Box Warningstherapy may cause delusionshallucinationspsychosisparanoiaconfusionand concentration disturbancesymptoms may abate with dose reduction.

Bupropion may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be alert.

Bupropion hydrobromide extended-release tablets are intended for oral use onlyinhalation of crushed tablets or injection of dissolved bupropion reportedseizures and/or cases of death reported when administered intranasally or by parenteral injection.

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plasma bupropion concentrations are dose-proportional following single doses of 100 to 250 mg; however, it is not known if the proportionality between dose and plasma level is maintained in chronic use.

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