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Benzodiazepines eg, lorazepam or other medicines for mental or mood problems because the risk of heart or breathing problems may be increased cimetidine, erythromycin, quinolone antibiotics eg, ciprofloxacin , risperidone, or selective serotonin reuptake inhibitors ssris eg, fluoxetine because they may increase the risk of clozaril s side effects barbiturates eg, phenobarbital , hydantoins eg, phenytoin , nicotine, or rifampin because they may decrease clozaril s effectiveness antiarrhythmics eg, propafenone, quinidine , anticholinergics eg, benztropine , carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure, phenothiazines eg, chlorpromazine , or tricyclic antidepressants eg, amitriptyline because the risk of their side effects may be increased by clozaril.

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If you are using the liquid form of this medicationread the Patient Information Leaflet if available from your pharmacist before you start taking clozapine and each time you get a refillIf you have any questionsask your doctor or pharmacist.

Because of the risks associated with Clozarilits use is limited to patients in whom therapy is indicated as set Cheap himcolin benefits out in section 4.1 and:

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