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Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorptionbioavailabilityof single doses of the followingcimetidinedigoxinfluoroquinolone antibioticsketoconazolel-thyroxinephenytoinquinidineranitidinetetracyclineand theophyllineSubtherapeutic prothrombin times with concomitant warfarin and sucralfate therapy have been reported in spontaneous and published case reportsHowevertwo clinical studies have demonstrated no change in either serum warfarin concentration or prothrombin time with the addition of sucralfate to chronic warfarin therapyThe mechanism of these interactions appears to be nonsystemic in naturepresumably resulting from sucralfate binding to the concomitant agent in the gastrointestinal tractIn all cases studied to datecimetidineciprofloxacindigoxinnorfloxacinofloxacinand ranitidinedosing the concomitant medication 2 hours before sucralfate eliminated the interactionDue to CARAFATE Oral Suspension’s potential to alter How much celebrex is safe to take the absorption of some drugsCARAFATE Oral Suspension should be administered separately from other drugs when alterations in bioavailability are felt to be criticalIn these casespatients should be monitored appropriately.
When sucralfate is administered orallysmall amounts of aluminum are absorbed from the gastrointestinal tractConcomitant use of sucralfate with other products that contain aluminumsuch as aluminum-containing antacidsmay increase the total body burden of aluminumPatients with normal renal function receiving the recommended doses of sucralfate and aluminum-containing products adequately excrete aluminum in the urinePatients with chronic renal failure or those receiving dialysis have impaired excretion of absorbed aluminumIn additionaluminum does not cross dialysis membranes because it is bound to albumin and transferrin plasma proteinsAluminum accumulation and toxicityaluminum osteodystrophyosteomalaciaencephalopathyhave been described in patients with renal impairmentSucralfate should be used with caution in patients with chronic renal failure.
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