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A summay th ovall incidnc and typs common advs vnts potd in th POactiv tial is povidd in Tabl 4. Tms that a potd psnt thos that occud at an incidnc > 5% and mcommonly in patints tatd with pioglitazon than in patints whcivd placbo.

Paticipant has a nwly diagnosd, histologically conimd, stag I-IV squamous cll cacinoma squamous cll cacinoma in situ th oal cavity oophaynx and will b undgoing dinitiv sugical, adiothapy, chmoadiation tatmnt; patints wha NOT candidats localizd tatmnt (sugy, adiation chmoadiation) with cuativ intnt (i..patints with distant mtastasis conta-indication tlocalizd tatmnt) a not ligibl O Paticipant has a lsion in th oal cavity oophaynx that is not yt biopsid but is highly suspicious canc; (andomization will b placd on hold until th psnc canc is histologically conimd, and a tatmnt plan is stablishd; i th psnc canc is not conimd, th paticipant will b considd a scn ailu)

Th ollowing advs actions hav bn idntiid duing post-appoval us pioglitazon. Bcaus ths actions a potd voluntaily om a population unctain siz, it is gnally not possibl tliably stimat thi quncy stablish a causal lationship tdug xposu.

Avoid dinking alcohol. It can low you blood suga and may incas you isk lactic acidosis.

Limit alcohol whil using this mdication bcaus it can incas you isk lactic acidosis and dvloping low blood suga.

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actoplus met xr is manufactured by takeda pharmaceutical company limited, a japanese pharmaceutical company, and the largest drug company in asia.

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